estelle doudement

Potential mechanisms for thrombocytopenia development

SigmaAldrich offers abstracts and fulltext articles by [Hirdesh Uppal, Estelle Doudement, Kaushiki Mahapatra, Walter C Darbonne, Daniela Bumbaca, BenQuan Shen, Xiaoyan Du, Ola Saad, Kristin Bowles, Steve Olsen, Gail D Lewis Phillips, Dylan Hartley, Mark X Sliwkowski, Sandhya Girish, Donna Dambach, Vanitha Ramakrishnan].

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Potential Mechanisms for Thrombocytopenia Development

Cancer Therapy: Preclinical Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (TDM1) Hirdesh Uppal1, Estelle Doudement1, Kaushiki Mahapatra1,Walter C. Darbonne2, Daniela Bumbaca3, BenQuan Shen3, Xiaoyan Du2, Ola Saad4, Kristin Bowles5, Steve Olsen6, Gail D. Lewis Phillips7, Dylan Hartley1, Mark X. Sliwkowski7, Sandhya Girish8, Donna Dambach9, and

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Potential Mechanisms for Thrombocytopenia Development with

Jan 01, 2015 · Purpose: Trastuzumabemtansine (TDM1) is an antibody–drug conjugate (ADC) comprising the cytotoxic agent DM1 conjugated to trastuzumab with a stable linker. Thrombocytopenia was the doselimiting toxicity in the phase I study, and grade ≥3 thrombocytopenia occurred in up to 13% of patients receiving TDM1 in phase III studies. We investigated the mechanism of TDM1–induced

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Safety and Efficacy of Trastuzumab Emtansine in Advanced

Advanced or metastatic breast cancer is an incurable disease with high mortality rate worldwide and about 20% of breast cancers overexpress and amplify the human epidermal growth factor receptor 2 (HER2). Achievements in targeted therapy have benefited people during the past decades. Trastuzumab emtansine (TDM1), a novel antibodydrug conjugate playing a powerful role in antitumor activity

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Scientists Investigate Potential Mechanisms for

Nov 06, 2014 · In a recent study, Hirdesh Uppal, Estelle Doudement, Kaushiki Mahapatra, and their colleagues at Genentech investigated the mechanism of TDM1induced thrombocytopenia. The results were published in the November 4, 2014 OnlineFirst edition of Clinical Cancer Research.

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Elodie Pouderoux (San Francisco, Etatsunis), occupe actuellement le poste de Clinical Specialist chez/à Medtronic USA. Voir son profil professionnel sur Viadeo.

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Papers with the keyword Reverse fusion (Page 4) Read by QxMD

Use Read by QxMD to access full text via your institution or open access sources. Read also provides personalized recommendations to keep you up to date in your field.

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Genentech: Sandhya Girish Senior Director and Senior

Working at Genentech is a dream come true you are in the midst of talented, passionate and extremely bright scientists who constantly motivate and inspire you to accomplish more. I feel fortunate to have the opportunity to implement clinical pharmacology and quantitative strategies and in bringing potential new treatment options to the forefront of patient care.

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Pharmacology Research & Perspectives British

Our journals promote pharmacology in all its forms by disseminating the latest high quality research in our peer reviewed scientific journals.

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Scientists Investigate Potential Mechanisms for

Nov 06, 2014 · In a recent study, Hirdesh Uppal, Estelle Doudement, Kaushiki Mahapatra, and their colleagues at Genentech investigated the mechanism of TDM1induced thrombocytopenia. The results were published in the November 4, 2014 OnlineFirst edition of Clinical Cancer Research.

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Potential mechanisms for thrombocytopenia development with

@article{Uppal2015PotentialMF, title={Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (TDM1).}, author={Hirdesh Uppal and Estelle Doudement and Kaushiki Mahapatra and Walter C. Darbonne and Daniela Bumbaca and By Delin Shen and Xiaoyan Du and Ola M Saad and Kristin

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Residential Markets EDFchair HEC Paris

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Potential mechanisms for thrombocytopenia development

SigmaAldrich offers abstracts and fulltext articles by [Hirdesh Uppal, Estelle Doudement, Kaushiki Mahapatra, Walter C Darbonne, Daniela Bumbaca, BenQuan Shen, Xiaoyan Du, Ola Saad, Kristin Bowles, Steve Olsen, Gail D Lewis Phillips, Dylan Hartley, Mark X Sliwkowski, Sandhya Girish, Donna Dambach, Vanitha Ramakrishnan].

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Pharmacology Research & Perspectives: Vol 6, No 6

Oct 25, 2018 · If the address matches an existing account you will receive an email with instructions to retrieve your username

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Publiions Authored by Annemarie Lekkerkerker PubFacts

Donna W Lee Shelly Zhong Rama Pai Julie Rae Siddharth Sukumaran Eric G Stefanich Jeff Lutman Estelle Doudement Xiaoting Wang Brandon Harder Annemarie Lekkerkerker Ann Herman Wenjun Ouyang Dimitry M Danilenko. Pharmacol Res Perspect 2018 12 156(6):e00434. Epub 2018 Nov 15. Genentech, Inc South San Francisco California USA.

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Florent Thomas (Busan, Corée) Viadeo

Tokyo, Japan [Supply Chain Dept. Planning. Team] In charge of short term and midterm planning for 5 brands ( 300milion € revenue). > Taking part in the monthly S&OP cycle by leading the demand planning part, elaborating forecast in collaboration with Marketing and Sales teams.

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(PDF) Nonclinical safety assessment of a human interleukin

Nonclinical safety assessment of a human interleukin22FC IG fusion protein demonstrates in vitro to in vivo and crossspecies translatability

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Estelle Doudement Sr Operations Manager JUMP Uber

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Estelle Doudement Inventions, Patents and Patent

Estelle Doudement has filed for patents to protect the following inventions. This listing includes patent appliions that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

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Trastuzumab SpringerLink

Trastuzumab (Herceptin ®, Genentech, Roche) is a recombinant humanized IgG1k monoclonal antibody binding with high affinity to the extracellular domain of the

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Papers in the journal Pharmacology Research & Perspectives

Although Interleukin22 (IL22) is produced by various leukocytes, it preferentially targets cells with epithelial origins. IL22 exerts essential roles in modulating various tissue epithelial functions, such as innate host defense against extracellular pathogens, barrier integrity, regeneration, and wound healing.

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Potential Mechanisms for Thrombocytopenia Development with

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (TDM1) Article (PDF Available) in Clinical Cancer Research 21(1) ·

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Nonclinical safety assessment of a human interleukin‐22FC

rinsed in cold PBS. PBS was removed and cells lysed in 100 μL/ well of 1X RIPA buffer, including protease and phosphatase inhibitors. Cell lysates were clarified by centrifugation at

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Estelle Doudement Sr Operations Manager JUMP Uber

View Estelle Doudement''s profile on LinkedIn, the world''s largest professional community. Estelle has 3 jobs listed on their profile. See the complete profile on LinkedIn and discover Estelle''s connections and jobs at similar companies.

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Papers with the keyword Reverse fusion (Page 4) Read by QxMD

Use Read by QxMD to access full text via your institution or open access sources. Read also provides personalized recommendations to keep you up to date in your field.

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Scientists Investigate Potential Mechanisms for

What are the potential mechanisms for thrombocytopenia in trastuzumab emtansine (TDM1)

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Potential mechanisms for thrombocytopenia development with

@article{Uppal2015PotentialMF, title={Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (TDM1).}, author={Hirdesh Uppal and Estelle Doudement and Kaushiki Mahapatra and Walter C. Darbonne and Daniela Bumbaca and By Delin Shen and Xiaoyan Du and Ola M Saad and Kristin

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Estelle Doudement Inventions, Patents and Patent

Estelle Doudement has filed for patents to protect the following inventions. This listing includes patent appliions that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

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(PDF) Potential Mechanisms for Thrombocytopenia

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (TDM1) Hirdesh Uppal,1a Estelle Doudement,1 Kaushiki Mahapatra,1 Walter C. Darbonne,2 Daniela Bumbaca,3 BenQuan Shen,3 Xiaoyan Du,2b Ola Saad,4 Kristin Bowles,5 Steve Olsen,6c Gail D. Lewis Phillips,7 Dylan Hartley,1d Mark X. Sliwkowski,7 Sandhya Girish,8 Donna Dambach,9 and Vanitha

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Proinflammatory role of the Th17 cytokine interleukin‐22

Proinflammatory role of the Th17 cytokine interleukin‐22

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WO2013174794A1 patents.google

Estelle DOUDEMENT Hirdesh Uppal Original Assignee F. HoffmannLa Roche Ag Genentech, Inc. Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) 20120523 Filing date 20130521 Publiion date 20131128

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Nonclinical safety assessment of a human interleukin‐22FC

rinsed in cold PBS. PBS was removed and cells lysed in 100 μL/ well of 1X RIPA buffer, including protease and phosphatase inhibitors. Cell lysates were clarified by centrifugation at

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Publiions Authored by Estelle Doudement PubFacts

Estelle Doudement. Estelle Doudement ABOUT PUBLICATIONS (2) NETWORK. PUBLICATIONS 2 Publiions by authors named "Estelle Doudement" 2Publiions. 50Reads. 46Profile Views. 1PubMed Central Citations. Nonclinical safety assessment of a human interleukin22FC IG fusion protein demonstrates in vitro to in vivo and crossspecies translatability.

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Genentech: Eric Stefanich Senior Scientist and Group

"The path to longevity at Genentech involves having a strong mentor/role model, trusted network of colleagues, and exciting opportunities." I am a Senior Scientist and Group Leader in the PTPK group within Development Sciences. I am accountable for the

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Hirdesh Uppal Inventions, Patents and Patent Appliions

Hirdesh Uppal has filed for patents to protect the following inventions. This listing includes patent appliions that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

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Salem Ben Yaala (San Francisco, Etatsunis) Viadeo

Salem Ben Yaala (San Francisco, Etatsunis), occupe actuellement le poste de Software Engineer chez/à Apple Inc.. Voir son profil professionnel sur Viadeo.

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New Opportunities for Stem Cells in Drug Discovery and

by Estelle Doudement and Hirdesh Uppal, Genentech Inc. Stem cells carry promises for regenerative medicine and cell therapy, but are also changing the drug discovery and development process. Stem cell models offer new opportunities to improve the manner in which pharmaceutical companies identify lead candidates and bring new drugs to the market.

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Genentech: BenQuan Shen Principal Scientist, PKPD

Genentech''s stimulating environment and opportunities to advance my career really attracted me here. I''m so excited to work with so many of the brightest and most innovative scientists to develop new treatments for some of the most difficulttotreat

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Publiions Authored by Estelle Doudement PubFacts

Estelle Doudement. Estelle Doudement ABOUT PUBLICATIONS (2) NETWORK. PUBLICATIONS 2 Publiions by authors named "Estelle Doudement" 2Publiions. 50Reads. 46Profile Views. 1PubMed Central Citations. Nonclinical safety assessment of a human interleukin22FC IG fusion protein demonstrates in vitro to in vivo and crossspecies translatability.

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Potential Mechanisms for Thrombocytopenia Development with

PDF Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (TDM1)

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Vincent Viudes Project Leader Global Strategy Group

View Vincent Viudes'' profile on LinkedIn, the world''s largest professional community. Vincent has 4 jobs listed on their profile. See the complete profile on LinkedIn and discover Vincent''s connections and jobs at similar companies.

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